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It was concluded that, overall, intensive insulin therapy increased the risk of hypoglycemia but provided no overall benefit on mortality in the critically ill, although a possible mortality benefit to patients admitted to the surgical ICU was suggested.

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NSAIDs with increasing degrees of relative cyclooxygenase-2 selectivity should not be administered to patients with NSTE-ACS and chronic musculoskeletal discomfort when therapy with acetaminophen, nonacetylated salicylates, tramadol, small doses of narcotics, or nonselective NSAIDs provide acceptable pain relief.

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Eight centers participated in the study, which was approved by the institutional review board at each site.

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As a larger body of evidence becomes available, recommendations and their grading levels are updated.

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In the placebo-controlled factorial design study, the population treated with a telmisartan and amlodipine combination had a mean age of 53 years and included approximately 50% males, 79% were Caucasian, 17% Blacks, and 4% Asians.

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The study gave a clear result: telmisartan provided equivalent efficacy to ramipril but with fewer discontinuations, whereas the combination was no more effective but was associated with worse tolerability.

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